Clinical development update: 1st dengue vaccine candidate
نویسندگان
چکیده
منابع مشابه
Development of Dengue Vaccine
The dengue viruses are estimated to cause several hundred thousand cases of dengue fever, dengue haemorrhagic fever and dengue shock syndrome annually. Attempts to prevent the infection focus on the development of a vaccine that would protect against all four serotypes of the dengue virus. Various biotechnological approaches are being explored, including the use of live attenuated or inactivate...
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Dengue is a major public health concern, resulting in significant morbidity, mortality, and economic and human costs, particularly in developing countries [1–4]. Approximately 40% of the world’s population lives in areas where dengue virus (DENV) transmission occurs, and dengue has recently become a threat in previously unaffected regions [5]. Cases of dengue, and its severe form, dengue haemor...
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The recent availability of significantly increased levels of funding for unmet medical needs in the developing world, made available by newly created public-private-partnerships, has proven to be a powerful driver for stimulating clinical development of candidate vaccines for malaria. This new way forward promises to greatly increase the likelihood of bringing a safe and effective vaccine to li...
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Dengue virus (DENV) represents a rapidly expanding global health threat, with approximately 40% of the world’s population now living in >100 countries at risk for DENV transmission, including the United States [1, 2]. In 2010, an estimated 390 million DENV infections occurred worldwide, of which 96 million were symptomatic [3]. DENV infections produce a spectrum of clinical disease. This includ...
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Dengue fever is a major tropical infectious disease that affects 50-100 million people each year. Its complications, namely dengue haemorrhagic fever and dengue shock syndrome, disproportionately afflict children and young adults. The primary goal of several vaccines now in development is to elicit protective neutralizing antibody responses; however, the exact definition of such responses remai...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical Sciences
سال: 2016
ISSN: 1818-0876
DOI: 10.1016/j.ajps.2015.10.014